Atrial Fibrillation with WPW

Normally, the atrioventricular node serves as the “gatekeeper” for signals arising from the atria – it has a refractory period that does not allow ventricular rates much faster than about 190. Accessory pathways have short refractory periods; therefore, signals can be transmitted at much faster rates with R-R intervals as low as 200 ms (i.e., 300 bpm). Patients with WPW and atrial fibrillation are at risk for deterioration and should be cardioverted. Procainamide or electrical cardioversion are the best options. Atrioventricular nodal blocking agents (e.g., beta blockers, adenosine, non-dihydropyridine calcium channel blockers, digoxin) should be avoided. If the atrioventricular node is blocked, the fibrillatory atrial signals will be transmitted indiscriminately via the accessory pathway, precipitating ventricular fibrillation.



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